Curcuma longa is often referred to Gold in the plant kingdom. Turmeric as it’s popularly known in the West or Haldi in India has held a place of great importance in socio-economic, religious and medicinal areas.
Curcumin is a major bioactive compound from the spice turmeric and exhibits anti-inflammatory, antioxidant, anticancer, antiviral, and neurotrophic activity and therefore holds promise as a therapeutic agent to prevent and treat several disorders. However, a major barrier to curcumin's clinical efficacy is its poor bioavailability. Animal, and human studies investigating the effects of curcumin on intestinal microbiota, intestinal permeability, gut inflammation and oxidative stress, anaphylactic response, and bacterial, parasitic, and fungal infections show positive changes in these areas and have wide-ranging influences on both intestinal and extraintestinal diseases.
Investigations also indicated curcumin's potential to treat several cancers, gastrointestinal diseases, metabolic diseases, dermatologic conditions, cardiovascular diseases, neurodegenerative diseases, autoimmune conditions, and psychiatric disorders. Presently, some of the strongest evidence for the therapeutic efficacy of curcumin (confirmed by meta-analytic analyses of randomized controlled trials) is for the treatment of arthritis , pain and analgesia and major depressive disorder. From a molecular standpoint, meta-analyses have also supported curcumin's ability to lower concentrations of C-reactive protein TNF-α and IL-6.
Despite these positive effects, a major criticism of curcumin is its poor bioavailability. In fact, some researchers have argued that given its unstable, reactive, and nonbioavailable nature, further clinical trials on curcumin are unwarranted Curcumin has been confirmed to exhibit very poor bioavailability, with many studies showing very low, or even undetectable, concentrations in blood and extraintestinal tissue. Major reasons postulated are due to its poor absorption, rapid metabolism, chemical instability, and rapid systemic elimination. The majority of oral curcumin is excreted in the feces (≤90%), as determined in several animal studies.
CYTOSTORM has been developed after years of study by India’s and one of the world’s top experts in herbal ingredients and phytotherapies, Amsar Goa. Based on research data generated by it’s inhouse research program Amsar Goa has solved this extremely difficult problem that has confounded the world so far. Amsar had developed a sublingual delivery method based on gelatine over a decade ago but was never satisfied using animal ingredients. Gelatine is produced from the bones of dead animals and with the growing concerns of contamination and viruses from major supply geographies Amsar has spent the past 5 years finding a 100% VEGAN solution.
CURCUMA EXTRACT IDENTITY AUTHENTICATED( 100% NATURAL)
Whilst the industry is known to be full of adulterated poor-quality products, Amsar Goa Pvt Ltd has spent 58 years researching natural products and has established itself as a global leader in natural products with several patents, research publications. We put all quality questions beyond doubt by being one of the few companies globally to authenticate the identity of every ingredient.
To understand the viability of cell line (MTT assay) and the molecular mechanism of inflammatory processes, various studies were conducted. The effect of the FDOT on the production of pro-inflammatory cytokines (TNF-α, IL-1 α) and anti-inflammatory cytokine (IL-10) were studied using mouse specific enzyme immune-assay kit. The cytokines TNF-α, IL-1α, IL-10 produced were quantified by ELISA and the results were compared.
Decrease in TNF –α and IL-1α cytokine by 81.61% and 90.88% and rise in IL-10 by 92.48% was occurred due to use of Cytostorm. Cytostorm IL has lowered the pro-inflammatory cytokine to 89.67% and 85.38% and elevated IL-10 level to108.27%. proving that CYTOSTORM IL is a potent anti-inflammatory product.